【摘要】 目的观察血液灌流串联血液透析(HP+HD)与血液透析滤过(HDF)联合促红细胞生成素(EPO)治疗对维持性血液透析(MHD)患者贫血的疗效。方法选择MHD贫血患者40例,随机均分成HP+HD组与HDF组,HP+HD组在每周2次常规HD的同时,每周行一次HP+HD;HDF组在每周2次常规HD的同时,每周行一次HDF;每次透析时间均为4小时。均接受促红素皮下注射,口服铁剂、叶酸补充造血原料。观察6个月,检测中小分子溶质及贫血指标。结果两组透析后小分子溶质的下降率无明显差异,中大分子溶质(β2-Mg、PTH、炎症因子等)的下降率HP+HD组优于HDF组,血红蛋白、血细胞比容上升HP+HD组亦优于HDF组,差异有显著性(P<0.05)。结论联合红细胞生成素的使用,HP+HD在保证对小分子量毒素充分清除的基础上,增加了对中大分子量毒素的清除,治疗尿毒症贫血较HDF更有效。更多还原

【Abstract】 Objective To compare the effects of hematopoietin therapy on maintenance hemodialysis(MHD)patients of anemia with blood perfusion in series with hemodialysis(HP+HD)or hemodialysis filtration(HDF).Method Choose MHD 40 patients,random anemia patients are divided into HP + HD group and HDF group.HP + HD group in weekly 2 times per week HD,regular once did HP + HD,HDF group in twice per week,weekly regular HD do a HDF,Each time for 4 hours dialysis.All accept promote red meat subcutaneous injection,oral iron,folic acid supplements hematopoietic materials agent.Observe 6 months,detection of small molecules solute and anemia index.Results Two sets of small molecules solutes after treatment,the decline rate no obvious difference in macromolecular solute(β 2 Mg,PTH),inflammation factors in HP + HD group,hemoglobin is HDF hematocrit value,rising HP + HD group,more than HDF group also has significant difference(P<0.05).Conclusion Combined the use of eryt HP + HD, in that small molecules to remove toxin,on the basis of the full weight has increased to remove toxin and cuhk uremia anemia treated more HDF more effective.更多还原