【摘要】 [目的]提高对急性白血病(AL)并发播散性热带念珠菌血症临床特征的认识。[方法]回顾性分析3例AL并发播散性热带念珠菌血症临床表现、诊治过程和转归。[结果]在3例患者中,中性粒细胞(ANC)缺乏时出现持续发热、鹅口疮;B超均发现肝内类圆形或椭圆形多发低回声,血培养均示热带念珠菌生长。3例患者采用两性霉素B(AmpB)联合5氟胞嘧啶治疗后体温正常。[结论]AL并发播散性热带念珠菌血症的诊断需结合病史、临床表现、实验室检查及影像学检查综合判断;选用两性霉素B联合5氟胞嘧啶治疗有较好的临床疗效。更多还原

【Abstract】 [Purpose] To improve the recognition of clinical characteristics of disseminated Candida tropicalis fungemia in patients with acute leukemia(AL). [Methods] Clinical manifestations, diagnosis, treatment and prognosis were retrospectively investigated in 3 cases of AL patients with disseminated Candida tropicalis fungemia. [Results] Of 3 cases, persistent fever and thrush occured during the time of agranulocytosis, spherical-like or oval multiple low-level echoes were detected in liver under type-B ultrasonic. Candida tropicalis was found by hemoculture. The temperature recovered normal after amphotericin B and flucytosin (5-FC) treatment in 3 cases. [Conclusion] The diagnosis of disseminated Candida tropicalis fungemia needs to be combined with clinical manifestation, laboratory examination and imaging examination. Combined amphoteriein B and flucytosin (5-FC) treatment has a favorable response.更多还原