【摘要】 [目的]探讨胃间质瘤(GST)临床病理特点、手术治疗及预后。[方法]回顾性分析1997～2007年间37例手术切除的GST临床病理资料。[结果]37例GST中肿瘤位于胃底部、胃体部、胃窦部分别为6例、11例、20例,肿瘤平均直径5.45±4.53cm。免疫组化分析CD117阳性表达率为97.0%。全组35例施行肿瘤完全切除术,另2例分别行姑息切除或活检。32例患者获随访,1、3、5年生存率分别为97.0%、88.2%、81.1%。Fletcher恶性风险分级与生存率密切相关(P=0.002),极低度、低度、中度风险组与高度风险组间生存率差异有显著性意义(P值均<0.05)。[结论]应高度重视GST初次手术的完全切除,对恶性风险较高的GST需积极施行切除范围较大的手术治疗。更多还原

【Abstract】 [Purpose] To investigate the clinicopathological features,surgical treatment and prognosis of gastric stromal tumor(GST). [Methods] The clinicopathological data of 37 patients with GST undergoing surgical treatment from 1997 to 2007 were analyzed retrospectively. [Results] Of 37 cases with GST,11 cases located at the fundus of stomach,20 cas-es at the gastric body,6 cases at the gastric antrum. The average diameter of tumors was 5.45 ±4.53cm. Positive expression rate of CD117 determined by immunohistochemical method was 97.0%.Thirty-five cases underwent complete tumor resection; 2 cases,palliative resection or biopsy. Of 32 cases followed up,the overall 1,3,5-year survival rate was 97.0%,88.2% and 81.1% respectively. Fletcher malignant risk grading for GIST closely related to survival rate(P=0.002). Survival rate among very low,low,intermediate and high-risk group was significantly difference (P<0.05 respectively). [Conclusion] Complete tumor resection for GST in the initial operation should be emphasized. Extended surgical resection is required for GST with higher malignancy risk.更多还原