【摘要】 [目的]探讨宫颈癌及食管癌组织中人乳头状瘤病毒(HPV)感染及其基因型分布的相关性。[方法]采用基因芯片方法分别检测200例宫颈癌和140例食管癌的HPV基因型,计算HPV感染率,分析HPV基因型与癌肿类型的关系。[结果]200例宫颈癌的HPV阳性率为94.00%(188/200),共检测到9种HPV基因型,其中主要基因型为HPV16(74.00%)和HPV18(16.00%),HPV双重感染的阳性率达12.00%(24/200)。169例宫颈鳞癌的HPV阳性率为95.86%,显著高于腺癌的80.00%(χ2=9.73,P<0.01),但HPV16、18和HPV双重感染在鳞、腺癌中的阳性率无显著性差异。在140例食管癌组织中,未检测到任何基因型别的HPV。[结论]宫颈癌组织的HPV感染型别多样,HPV16、18为最常见类型,HPV感染更常见于宫颈鳞癌。但HPV各型别的分布与癌肿类型无关,HPV似乎与食管癌的发生无关。更多还原

【Abstract】 [Purpose] To explore the association of human papillomavirus (HPV) prevalence and genotypes distribution in cervical cancer and esophageal cancer. [Methods] HPV genotypes of 200 cases with cervical cancer and 140 cases with esophageal cancer were detected by gene chip. The relation of HPV genotypes with cancer types was investigated. [Results] The positive rate of HPV was 94.00%(188/200) in 200 cases with cervical cancer. Nine HPV genotypes were found and the most common types were HPV16(74.00%) and HPV18(16.00%). The positive rate of double HPV infection was 12.00%(24/200). The HPV positive rate in cervical squamous cancer was significantly higher than that in adenocarcinoma (95.86% vs. 80.00%,χ2=9.73,P<0.01),but no significant difference in the positive rate of HPV16,18 and double infection between squamous cancer and adenocarcinoma. HPV with any genotype was not found in 140 cases with esophageal cancer. [Conclusions] HPV has many genotypes in cervical cancer tissue and HPV16,18 are the most common types. HPV infection rate in squamous cancer is higher than that in adenocarcinoma. But the HPV genotypes distribution does not correlate with the cancer types. HPV infection seems no correlation with esophageal cancer.更多还原