【摘要】 目的:观察幽门螺杆菌(Hp)感染是否与不稳定型心绞痛(UAP)有关联。方法:152例住院的心绞痛患者分为两组:UAP组患者114例,对照组为稳定型心绞痛(SAP)患者38例。所有患者应用ELISA法测定血清Hp-IgG浓度,测定血清高敏C反应蛋白(hsCRP)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)浓度,行冠状动脉造影检查,以Gensini冠状动脉积分评价冠状动脉狭窄程度。结果:UAP组患者的血清Hp-IgG、hsCRP、空腹血糖(FPG)水平和冠状动脉积分均高于SAP组患者(P<0.05),采用多因素Logistic回归分析表明,血清Hp-IgG(OR=5.13,95%CI1.91-13.78,P<0.01)、hsCRP(OR=3.58,95%CI1.32-9.65,P<0.05)和FPG(OR=6.20,95%CI1.21-31.42,P<0.05)水平升高的3个指标与UAP有关。结论:血清Hp-IgG水平升高与UAP有关。更多还原

【Abstract】 AIM: To observe the relationship between Helicobacter pylori(Hp) infection and unstable angina pectoris(UAP).METHODS: One hundred and fifty-two patients with angina pectoris from Tianjin Medical University Hospital were divided into UAP group(n=114) and stable angina pectoris group(SAP,n=38).The concentration of the Ig-G antibodies to Hp(Hp-IgG) was determined by enzyme-linked immunosorbent assay(ELISA).The concentration of the high-sensitivity C-reactive protein(hsCRP),total cholesterol(TC),triglyeride(TG),high-density lipoprotein cholesterol(HDL-C),and low-density lipoprotein cholesterol(LDL-C) were determined.Coronary angiography was performed in all patients to assess the degree of coronary artery stenoses.RESULTS: Levels of serum Hp-IgG,hsCRP and FPG were higher in UAP group than in control group.Multivariate logistic regression analysis showed that the higher levels of Hp-IgG(OR=5.13,95%CI 1.91-13.78,P<0.01),hsCRP(OR=3.58,95%CI 1.32-9.65,P<0.05) and FPG(OR=6.20,95%CI 1.21-31.42,P<0.05) were risk factors for UAP patients.CONCLUSION: The concentration of serum Hp-IgG is higher in UAP patients.The higher level of Hp-IgG is significantly associated with UAP.更多还原