【摘要】 目的:研究高血压病患者左室舒张功能不全治疗的最佳方案。方法:将60例门诊高血压病患者随机分为3组:氨氯地平组给予苯磺酸左旋氨氯地平5 mg每晚1次;依那普利组给予马来酸依那普利10 mg每日2次;联合用药组给予苯磺酸左旋氨氯地平2.5 mg每晚1次+马来酸依那普利5 mg每日2次。对比治疗前和6个月后随访时的左室射血分数(LVEF)、心电机械图S2至E峰时间(IVRT)、二尖瓣血流峰值速度E/A,并对比各组中不良反应的发生率。结果:3组内治疗前后LVEF无显著性差异;IVRT、E/A改善具有显著性。3组间治疗后结果比较LVEF、IVRT均无统计学差异,联合用药组E/A较单独用药组具有统计学差异(均P<0.05)。结论:对伴有左心室舒张功能不全的高血压病患者,氨氯地平和依那普利对舒张功能的指标均有改善;而氨氯地平和依那普利小剂量联合使用,对舒张功能的指标E/A有更显著地改善,且副作用发生率较低。更多还原

【Abstract】 AIM: To explore a better therapy program for hypertensive patients with left ventricular diastolic dysfunction.METHODS: Sixty hypertensive out-patients were randomly divided into three groups: Group 1 treated with levamlodipine besilate(5 mg) nightly,Group 2 treated with enalapril maleate(10 mg) twice daily,and Group 3 treated with levamlodipine besilate(2.5 mg) nightly plus enalapril maleate(5 mg) twice daily.LVEF,IVRT,E/A,and side effects were recorded before treatment and 6 months after treatment.RESULTS: LVEF of the three groups before and after treatment showed no significant differences.IVRT and E/A improved significantly(P<0.05).After treatment,LVEF and IVRT showed no significant difference among the three groups.Compared with that in Group 1 and Group 2,Group 3 E/A was significantly different(P<0.05).CONCLUSION: In the treatment of hypertensive patients with diastolic dysfunction,levamlodipine besilate and enalapril maleate improve the indicator of diastolic function.The combination of low-dose levamlodipine besilate and enalapril maleate significantly improves the E/A with few side effects.更多还原