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低声压级水平次声对心肌梗死大鼠心功能的影响及机制

Effects of low decibel infrasound on heart function after acute myocardial infarction in rats

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【Author】 LIU Zhao-hong1,CHU Guo-liang2,ZHU Miao-zhang3,CHEN Jing-zao4,ZHUANG Zhi-qiang5,PEI Zhao-hui6(1.Department of Geriatrics,PLA 107 Hospital,Yantai 264002,Shandong,China;2.Deparment of Anatomy,SUN Yat-sen University of Medical Sciences,Guangzhou 510080,Guangdong,China;3.Department of Physiology,Fourth Military Medical University,Xi’an 710032,Shaanxi,China;4.Department of Physical Therapy & Rehabilitation,Xijing Hospital,Fourth Military Medical University,Xi’an 710032,Shaanxi,China;5.Department of Rehabilitation,Second Affiliated Hospital,SUN Yat-sen University of Medical Sciences,Guangzhou 510120,Guangdong,China;6.Department of Cardiology,First Affiliated Hospital,SUN Yat-sen University of Medical Sciences,Guangzhou 510080,Guangdong,China)

【机构】解放军第107中心医院老年病科；中山大学中山医学院解剖学教研室；第四军医大学基础部生理学教研室；第四军医大学西京医院理疗康复科；中山大学附属第二医院康复科；中山大学附属一院心内科；

【摘要】目的:观察次声对心肌梗死大鼠心功能的影响及相关的机制。方法:将30只SD大鼠随机分为3组,即假手术组(对照组)、心肌梗死组及次声治疗组,每组10只。采用次声治疗仪对心肌梗死大鼠进行治疗1周(2次/d,0.5 h/次),观察心肌细胞超微结构的改变,血浆NO和内皮素-1(ET-1)水平的变化以及大鼠心功能的变化。结果:与心肌梗死组大鼠比较,次声治疗组大鼠心肌超微结构损伤减轻,血浆NO含量增加(P<0.01),血浆ENT-1含量减少(P<0.01),心功能明显改善(P<0.01)。结论:低声压级水平次声治疗能够显著改善心肌梗死后大鼠心脏功能。更多还原

【Abstract】 AIM: To observe the changes of heart function and its underlying mechanism after acute myocardial infarction in rats.METHODS: Rats were treated for 7 days,0.5 h daily,2/day with infrasound therapy apparatus.The ultrastructure of rat myocardium,contents of NO and NET-1 in rat plasma and heart function were observed.RESULTS: Compared with control group,ultrastructual damage of rat myocardium in infrasound treatment group was attenuated,contents of NO in rat plasma werr significantly increased(P<0.01),contents of ENT-1 in rat plasma was significantly decreased(P<0.01),and the heart function of rats was significantly improved(P<0.01).CONCLUSION: Rat heart function following infarction can be improved with infrasound treatment.更多还原

【关键词】次声；大鼠；超微结构；心肌梗死；
【Key words】 infrasound； rat； ultrastructure； myocardium；

【基金】中国博士后科学基金项目资助(20080430805);国家自然科学基金项目资助(30870579)

【文献出处】心脏杂志 ,Chinese Heart Journal , 编辑部邮箱 ,2009年05期

【分类号】R542.22
【被引频次】6
【下载频次】86

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