【摘要】 目的了解充血与缺血性心力衰竭(HF)时超氧化物歧化酶(SOD)及其相关微量元素细胞内外变化特征,为HF患者微量元素治疗提供依据。方法用放射免疫法测定27例急诊HF患者维生素C抗氧化治疗前后血清SOD,用日立180-80原子吸收分光光度计测定血浆及红细胞内外微量元素Cu,Zn,Se,Fe。结果充血性HF(CHF)与缺血性心脏病伴心功能不全患者[缺血性HF(IHF)]及二者与正常组比较SOD均无显著差异。CHF治疗前后红细胞Se,Fe,Cu与正常组比较差异显著(P<0.01),治疗前后血浆Zn降低、Cu升高,与正常组比较差异显著(P<0.01)。治疗前血浆Se与正常组比较降低且有显著差异(P<0.05)。IHF治疗前后红细胞Se,Fe,Cu与正常组比较均降低且差异显著(P<0.01),治疗前后血浆Cu升高、Zn降低,与正常组比较差异显著(P<0.01)。IHF红细胞治疗后较治疗前Cu升高、Zn降低(均P<0.05)。IHF治疗前血浆Cu低于CHF组(P<0.05)。结论经维生素C抗氧化治疗血清SOD水平可接近正常水平,但危重HF患者与SOD相关微量元素代谢明显紊乱,尚需根据CHF与IHF不同特征补充微量元素。更多还原

【Abstract】 AIM To investigate the changes of superoxide dismutase(SOD) and trace elements in patients with congestive heart failure(CHF) or ischemic heart failure(IHF) before and after vitamin C treatment.METHODS Blood SOD and trace element levels were analyzed in 27 cases of emergence CHF and IHC subjects and the results were compared before and after vitamin C treatment.RESULTS No significant difference in serum SOD levels was observed between CHF and IHF.CHF group had much lower Se,Fe,and Cu in red blood cells compared to those in normal subjects(P<0.01).Plasma levels of Cu,Zn,Se had significant difference compared with those in normal subjects(P<0.05,P<0.01) before and after vitamin C treatment.In IHF group,Se,Fe,Cu levels of red blood cell were significant lower than those in normal subject(P<0.01) and significant difference was found in the plasma levels of Cu and Zu compared with those in normal subjects(P<0.01) before and after vitamin C treatment.Cu and Zu in red blood cell were significantly increased and decreased post-treatment(P<0.05).CONCLUSION SOD level can be maintained close to normal after vitamin C treatment in patients with CHF or IHF.Trace element supplement should be provided for disorder of SOD-related trace element in patients with serious heart failure.更多还原