【摘要】 目的探讨并分析SLE(系统性红斑狼疮)患者外周血T细胞亚群占CD4+T细胞的百分比,以阐述其临床意义。方法流式细胞术检测34例SLE初诊、20例复发和35例治疗后病例外周血T细胞亚群占CD4+T细胞的百分比,并以39例健康体检者作为正常对照,同时观察上述检测指标与SLEDAI(狼疮活动指数评分)、GLB(血清球蛋白)、IgG(免疫球蛋白)、ESR(血沉)、C3、C4的关系。结果SLE初诊患者外周血T细胞亚群占CD4+T细胞的百分比显著低于复发、治疗后及正常对照组(p<0.01),活跃期亦显著低于稳定期(p<0.05),与ESR、GLB、C3、C4、IgG有相关性。结论T细胞亚群改变可能是导致SLE发生和病情发展的关键。更多还原

【Abstract】 Objective To explore the clinical significance by investigating and analyzing the percentage of T cell subpopulation in CD4+T cell in the peripheral blood of patien ts with SLE.,Methods Thirty-four SLE patients of preliminary diagnosis and twenty SLE patients of relapse and thirty-five SEL patients of post-treatment and thirty-nine healthy individuals were studied,the percentage of T cell subpopulation in CD4+T cell in the peripheral blood was detected by flow cytometry(FCM),the relationship of ESR,GLB,C3,C4,IgG and the percentage of T cell subpopulation were observed.Results Compared with another three cases,the percentage of T cell subpopulation in CD4+T cell from thirty-four SEL patients of preliminary diagnosis was the lowest(p< 0.05),so is in active stage,significant correlation was found between the levels of the percentage of T cell subpopulation in CD4+T cell and other serological parameters including ESR,GLB,C3,C4,IgG.Conclusion T cell subpopulation may play an important role in the pathogenesis and progression of SLE.更多还原