【摘要】 [目的]研究糖尿病肾病的影响因素,探讨不并发糖尿病肾病的空腹血糖控制水平。[方法]运用回顾性调查的方法,对糖尿病及糖尿病肾病病人进行相关资料收集,对数据进行非条件Logistic回归分析,寻找糖尿病发展到糖尿病肾病阶段的危险因素,并结合有序回归、ROC曲线的分析方法,确定糖尿病肾病的空腹血糖控制水平。[结果]糖尿病发展到糖尿病肾病阶段的危险因素为收缩压、糖尿病病程、空腹血糖、空腹C肽。预防糖尿病肾病的血糖安全参考值为8.4 mmol/L,95%可信区间为8.1～8.8 mmol/L。[结论]通过建立ROC曲线方程,就可得到相应的血糖安全参考值,进而判断出在该安全参考值下,判定为阴性的患者真正不并发糖尿病肾病的可能性。高血糖是导致糖尿病及其并发症的根本原因,血糖的严格控制,是控制糖尿病及其并发症的最根本措施。更多还原

【Abstract】 [Objective] To study the influential factors of diabetic nephropathy and investigate the control level of fasting blood glucose to avoid diabetic nephropathy.[Methods] Collected the data related with diabetes and diabetic nephropathy patients by retrospective study,analyzedthe data by non-conditional Logistic regression analysis method to search the risk factors of diabetes turning to diabetic nephropathy.Analyzed the data combined with Ordinal Regression statistic and Receiver Operating Characteristic(ROC) methods to make sure the control level of fasting blood glucose of avoiding diabetic nephropathy.[Results] The risk factors of diabetes turning to diabetic nephropathy were contractive pressure,course of disease,fasting blood glucose,empty stomach C peptide.The reference value of blood glucose for preventing diabetic nephropathy was 8.4 mmol / L,and the 95% confidence interval was between 8.1 mmol / L and 8.8 mmol / L.[Conclusion] The safety reference value of blood glucose can be obtained by establishing ROC curve equations,which can infer the possibility of not suffering the diabetic nephropathy complication among the people whose blood glucose are under the safety reference value.Hyperglycosemia is the crucial reason that leads to diabetic and its complications,the key measure to prevent diabetic and its complications is controlling the blood glucose level.更多还原