【摘要】 [目的]探讨1997～2007年中国住院分娩的围产儿中唐氏综合征的流行病学特征。[方法]采用中国出生缺陷监测网的资料,调查住院分娩的孕28周到产后7d内围产儿中唐氏综合征患儿发生情况。[结果]调查围产儿数5886108例,唐氏综合征患儿1421例,发生率2.41/万。活产患儿占79.31%。男性为2.45/万、女性2.35/万。城市发生率2.84/万、农村1.50/万,沿海、内地、边远地区发生率分别为3.25/万、1.90/万和1.82/万,城乡之间、地区之间差异均有统计学意义。全国年度发生率总体呈上升趋势(P﹤0.05),2004年以后不同地区年度发生率先后出现下降现象(P﹥0.05)。产妇年龄别发生率以≥35岁年龄组最高(9.42/万),各年龄组间有显著性差异。高龄孕妇所分娩的围产儿及患儿比例呈上升趋势。[结论]中国住院分娩的围产儿中唐氏综合征的发生存在明显城乡和地区差异;年度发生率总体呈上升趋势,2004年后发生率连续4年下降,尽管下降趋势还没有统计学意义,但已经显现出中国近年来开展的针对唐氏综合征预防措施初见成效,同时患儿活产率高、高龄产妇分娩围产儿和患儿比例逐年上升现象值得关注。更多还原

【Abstract】 [Objective] To explore the epidemiological characteristics of perinatal Down’s syndrome in Chinese maternity hospital from 1997 to 2007.[Methods] According to the information from Chinese Birth Defects Monitoring Network,the incidence of Down’s syndrome was investigated in the inhospital infants from pregnant 28 weeks to postnatal 7 days.[Results] 5 886 108 cases of perinatal infants were investigated,and Down’s syndrome was detected in 1 421 cases,with the incidence of 2.41 /10 000,in which male with 2.45 /10 000 and female with 2.35 /10 000.The incidence was 2.84 /10 000 in urban area and 1.50 /10 000 in rural area.The incidences of coastal,inland,and remote areas was 3.25 /10 000,1.90 /10 000 and 1.82 /10 000,respectively,and there were significant differences between urban and rural areas,and among the regions.The overall annual incidence of whole country rose,in which the annual incidence significantly increased from 1997 to 2003 year by year(P﹤0.05),and the obvious decreases took place in different areas early or late from 2004 to 2007 year(P﹥0.05).The group that the maternal age older than 35 year had the highest incidence(9.42 /10 000),and there was significant difference among all age groups.The numbers of infants and infants with Down’s Syndrome from women with advanced maternal age tended to rise.[Conclusion] There are significant urbanrural and regional differences in the incidences of the Down’s Syndrome in China;the overall annual incidence Down’s Syndrome is upward,but successively downward after 2004,although with no statistical significance.The preventive measures to Down’s syndrome has demonstrated the initial effects in our country,and the affected infants have high survival rates,while it need to be concerned that the numbers of infants and infants with Down’s Syndrome from women with advanced maternal age tend to rise.更多还原