【摘要】 [目的]了解闽清县乙型肝炎感染状况及发病规律,分析其流行因素,为制订该县乙型肝炎预防控制策略提供科学依据。[方法]采用整群抽样法,以家庭为单位进行随机抽样,用酶联免疫吸附试验(ELISA)检测乙肝两对半,用EpiDate3.01建立数据库,并采用SPSS13.0进行统计分析。[结果]共调查1409人,HBV感染率为65.79%,HBsAg阳性率为9.65%,抗-HBs阳性率为43.36%,HBeAg阳性率为2.34%,抗-HBe阳性率为13.91%,抗-HBc阳性率为59.61%。共有17种感染模式,以5项全阴模式居首位。HBsAg阳性率男性高于女性,从年龄分布来看,HBsAg阳性率呈中间高、两头低的趋势,15岁以下儿童HBsAg阳性率仅为2.93%(8/273),以20～24岁组最高达20.0%。有乙肝疫苗免疫史的人,其HBsAg阳性率、抗-HBe阳性率、抗-HBc阳性率均低于无免疫史的人。既往有医疗行为者HBsAg阳性率高于无医疗行为者。[结论]在继续做好新生儿乙肝疫苗免疫接种的同时,应进一步扩大疫苗免疫范围。严格血液及血制品和医疗机构消毒管理工作,这样才能有效遏制乙型肝炎发病的上升势头。更多还原

【Abstract】 [Objective] To investigate the infection status and incidence of hepatitis B and its epidemic status in Minqing County,so as to provide scientific basis for preventing and curing the hepatitis B.[Methods] Family-based cluster random sampling method was performed in this study.Enzyme linked immunosorbent assay(ELISA) was performed to determine serum marker of hepatitis B.Epidate 3.01 and SPSS13.0 were used to establish database and analyze the data.[Results] A total of 1 409 members were examined.The rate of HBV infection was 65.79%,The masculine rate of HBsAg,HBsAb,HBeAg,HBeAb and HBcAb were 9.65%,43.36%,2.34%,13.91% and 59.61%,respectively.There were 17 HBV infection models.Five indexes that were all negative model showed to be the highest incidence of all the models.The positive rate of HBsAg in male was higher than female.The peak age of HBV was concentrated in the 20 to 24 years old with the HBV incidence of 20.0%,while the incidence of HBV among people below 15 years old 2.93%(8 /273).The positive rates of HBsAg,HBeAb and HBcAb among the people with immunization were lower than those among the people without immunization,while the HB-sAb positive rate among people with medical treatments was higher than those the people without.[Conclusion] We should expand the coverage of HBV immunization and newborn immunization,also we should strengthen of management of blood,blood products and sterilization,so that we can effectively control the incidence of HBV.更多还原