【摘要】 目的测定匹诺塞林在不同浓度羟丙基-β-环糊精溶液中的溶解度曲线,以及包合物的组成量比例和稳定性常数。方法在25℃运用相溶解度法进行实验,采用紫外分光光度法测定匹诺塞林在溶液中的浓度。结果随着羟丙基-β-环糊精浓度增加和pH的增大,匹诺塞林的溶解度显著提高。计算了表观稳定常数、确定了不同pH条件下包合物的摩尔比。结论难溶性药物匹诺塞林与羟丙基-β-环糊精可形成1∶1包合物。更多还原

【Abstract】 OBJECTIVE To investigate the solubilization effects of the inclusion complex of pinocembrin with hydroxypropyl-β-cyclodextrin (HP-β-CD) in aqueous solutions at various pH and to determine the constitutive molar ratio of pinocembrin-hydroxypropyl-β-cyclodextrin inclusion complex and its stability constant. METHODS The solubilization experiment was performed by the phase-solubility method at 25 ℃.The concentration of pinocembrin was determined by the UV spectrophotometric method.RESULTS The apparent solubility of pinocembrin was enhanced noticeably with the increase of HP-β-CD concentration and the increasing pH values.The apparent stability constants were calculated respectively.The molar ratio of the inclusion complex at various pH were studied.The application of HP-β-CD to parenteral formulations of pinocembrin was discussed preliminarily.CONCLUSION An inclusion complex of pinocembrin and HP-β-CD can be formed.更多还原