【摘要】 目的:探讨纤维蛋白原在心血管支架置入前后的变化及其影响。方法:用计算机检索中国期刊全文数据库(CNKI:1994/2009)和Medline database(1994/2009),按纳入和排除标准,对文献进行筛选,资料收集和质量评价,共纳入26篇文章。从心血管疾病患者体内纤维蛋白原的变化,心血管支架置入对纤维蛋白原的影响及在心血管支架置入过程使用抗凝药物对纤维蛋白原的作用3方面进行总结。结果:心血管疾病患者大都存在纤维蛋白原的异常变化,心血管支架置入会刺激血管内皮细胞,使血液凝血-纤溶系统的失衡,改变纤维蛋白原含量,引起并发症的发生。在置入后使用抗凝药物,也会对纤维蛋白原产生影响,使治疗出现不同的效果。结论:纤维蛋白原在心血管支架置入的变化及置入后抗凝药物对其的影响,值得进一步关注。更多还原

【Abstract】 OBJECTIVE: To investigate the changes of fibrinogen before and after cardio-vascular stent implantation. METHODS: A computer-based online search was conducted in CNKI and Medline database between 1994 and 2009. A total of 26 articles were included in accordance with inclusion and exclusion criteria. This study was designed to summarize changes of fibrinogen, effect of cardio-vascular stent implantation on fibrinogen, and effect of anticoagulant on fibrinogen. RESULTS: Abnormal changes of fibrinogen were detected in patients with cardiovascular disease. Cardio-vascular stent implantation might stimulate vascular endothelial cells so as to destroy balance between blood coagulation and dissolving system, change content of fibrinogen, and induce complications. Additionally, anticoagulant might also influence generation of fibrinogen and cause varying therapeutic effects. CONCLUSION: The effect of anticoagulant on fibrinogen content before and after cardio-vascular stent implantation needs to be further studied.更多还原