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掺锶羟基磷灰石的材料学特性及其生物学评价

Characteristics and biological evaluation of strontium-doped calcium phosphate

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【作者】 叶冬平梁伟国周子强

【Author】 Ye Dong-ping,Liang Wei-guo,Zhou Zi-qiang Department of Orthopaedics,Fourth Affiliated Hospital of Jinan University (Guangzhou Red Cross Hospital),Guangzhou 510220,Guangdong Province,China

【机构】 暨南大学第四附属医院(广州市红十字会医院)骨科

【摘要】 可注射性磷酸钙材料是目前临床骨科解决骨组织缺损和破坏的潜在理想替代物。但其材料学特性及生物学评价仍有待于提高。因此材料学界和骨科学界对磷酸钙骨水泥进行了各种改性研究,其中锶的加入明显改善了骨水泥的各项性能。文章详细研究了掺锶磷酸钙骨水泥的抗压强度、降解性、固化时间、溶解性、注射性和抗水溶性、分析了掺锶磷酸钙骨水泥的临床应用。展望了掺锶磷酸钙骨水泥作为骨组织修复领域中人工骨替代材料的应用前景。

【Abstract】 The injectable calcium phosphate material is present to solve the clinical bone defects of bone tissue and the potential to undermine the ideal substitute. But the properties and biological evaluation are still to be improved. Therefore,the material of the academic community and the academic orthopedic bone cement was modified for a variety of studies,and the addition of strontium bone cement significantly improved the performance. The article indicated strontium-mixed calcium phosphate bone cement was characterizing by the compressive strength,the degradability,the hardening time,the solubility,the injection and the anti-water-solubility,suggesting the clinical practice of the strontium-mixed calcium phosphate bone cement. Prospectively,the strontium-mixed calcium phosphate bone cement may take in the bone tissue repair domain as a artificial bone substitution material.

【基金】 广州医药卫生科技重点项目(2007-Zdi-11)~~
  • 【文献出处】 中国组织工程研究与临床康复 ,Journal of Clinical Rehabilitative Tissue Engineering Research , 编辑部邮箱 ,2009年34期
  • 【分类号】R318.08
  • 【被引频次】4
  • 【下载频次】304
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