【摘要】 目的:探讨血清甲壳质酶蛋白40(YKL-40)、人附睾蛋白4(HE4)在上皮性卵巢肿瘤的表达及临床意义。方法:用酶联免疫吸附试验,检测健康妇女、上皮性良性卵巢肿瘤、交界性卵巢肿瘤及卵巢癌患者血清中YKL-40、HE4的水平。结果:(1)健康妇女、上皮性良性卵巢肿瘤、交界性卵巢肿瘤及卵巢癌患者术前血清中,YKL-40表达中位数分别为35.56、41.42、44.34和130.25μg/L;HE4的表达中位数分别为41.10、43.98、65.21和260.90pmol/L;在术前卵巢癌组YKL-40、HE4的表达水平均高于前3组,差异有统计学意义(P<0.05),前3组之间差异无统计学意义;卵巢癌患者术后血清中YKL-40、HE4中位数分别为58.57μg/L、124.32pmol/L,术前血清水平明显高于术后(P<0.05);(2)卵巢癌患者术前血清YKL-40浓度与FIGO分期、血清CA125浓度呈正相关(P<0.05);术前血清HE4浓度与病理类型、血清CA125浓度、年龄相关。结论:血清YKL-40、HE4有望成为卵巢癌标志物,用于早期诊断和预后分析。更多还原

【Abstract】 Objective:To explore the expressions and significance of serum YKL-40,human epididymis protein 4(HE4)in patients with epithelial ovarian tumor.Methods:The enzyme-linked immuno-sorbent assay(ELISA)technique was applied to detect serum YKL-40 and HE4 levels in healthy women and patients of benign ovarian tumor,borderline ovarian tumor,and ovarian carcinoma.Results:(1)In healthy women,benign ovarian tumor,borderline ovarian tumor,preoperative ovarian carcinoma,the serum YKL-40 median levels were 35.56,41.42,44.34,130.25μg/L respectively.The serum HE4 median levels were 41.10,43.98,65.21 and 260.90 pmol/L respectively.The preoperative median levels of YKL-40,HE4 in ovarian carcinoma group were significantly higher than those of the former three groups(P<0.05).The former three groups were further compared,no statistically significant difference was found respectively(P>0.05).In ovarian carcinoma group,the median postoperative YKL-40,HE4 levels were 58.57μg/L,124.32pmol/L,the levels of preoperative were significantly higher than postoperative levels(P<0.05).(2)In ovarian carcinoma group,the preoperative serum YKL-40 levels positively correlated with stage,the concentration of CA125.The preoperative serum HE4 levels associated with pathological types,the concentration of CA125 and patients’age.Conclusion:Serum YKL-40,HE4 levels can be seen as biomarkers of the ovarian carcinomas.更多还原