【摘要】 目的:研究儿童喉乳头状瘤中survivin及caspase-3蛋白的表达及其相互关系。方法:应用免疫组化方法对儿童喉乳头状瘤组织、儿童声带小结组织及正常的喉黏膜组织中survivin及caspase-3的表达进行检测并进行相关性分析。结果:42例儿童喉乳头状瘤组织中survivin阳性表达率为57.14%,明显高于儿童声带小结组(P<0.01)和正常黏膜组(P<0.01);42例喉乳头状瘤组织中caspase-3阳性表达率为26.19%,显著高于儿童声带小结组和正常喉黏膜组(P<0.01);Spearman相关性分析显示,儿童喉乳头状瘤中survivin与caspase-3的表达呈显著负相关(r=-0.682,P<0.01)。结论:Survivin的高表达和caspase-3的低表达可能在儿童喉乳头状瘤发生发展过程中起着重要作用。更多还原

【Abstract】 AIM: To investigate correlation between the expression of survivin and caspase-3 proteins in juvenile laryngeal papilloma.METHODS: The expression of survivin and caspase-3 proteins were detected with immunohistochemial method in 43 cases of juvenile laryngeal papilloma,25 vocal nodules and 25 normal laryngeal mucosa.RESULTS: The positive rates of survivin protein in juvenile laryngeal papilloma were 57.14% and higher than that in voeal nodules(P<0.01)and the normal laryngeal moeusa(P<0.01).And the Caspase-3 protein positive rate was 26.19% in juvenile laryngeal papilloma and lower than that in voeal nodules and the normal laryngeal mucosa(P<0.01).There was a significant negative correlation between the expression of survivin and caspase-3 in juvenile laryngeal papilloma.CONCLUSION: The abnormal expression of survivin and caspase-3 may play important role in the pathogenesis of juvenile laryngeal papilloma.更多还原