【摘要】 目的探讨新疆哈萨克族原发性高血压与HLA-DQA1等位基因的相关性。方法应用病例-对照相关性分析方法及PCR-SSP基因分型技术对新疆哈萨克族健康个体83例和高血压病患者80例(均无血缘关系),进行了HLA-DQA1等位基因分型。结果原发性高血压患者中DQA1*0301的频率为21.591%,显著高于对照组(10.345%),χ2=4.770,P<0.05,OR=2.561。DQA1*0103的频率(19.318%)显著低于对照组(34.483%),χ2=4.404,P<0.05。OR=0.477。结论HLA-DQA1*0301可能与新疆哈萨克族原发性高血压易感相关,而HLA-DQA1*0103可能在新疆哈萨克族原发性高血压发病中有保护作用。更多还原

【Abstract】 Objective To investigate the relationship between the alleles of human leukocyte antigens (HLA) DQA1 and essential hypertension (EH) in Xinjiang Kazak population in China. Methods Alleles of HLA-DQA1 were typed by polymerase chain reaction-sequence specific primers techniques in samples of 80 EH patients and 83 healthy people in case-control study (EH patients and healthy people as controls had no consanguinity with each other). Results The frequency of DQA1*0301 was 21.591%,significantly higher in the EH patients than in the controls (10.345%) (χ2=4.770,P<0.05). Odds ratio (OR) was 2.561.The frequency of DQA1*0103 significantly decreased in the group of patients with EH in comparison to the controls (19.318% vs. 34.483%) (χ2=4.404,P<0.05). OR was 0.477. Conclusion HLA-DQA1*0301 was related to the susceptibility of essential hypertension in the Xinjiang Kazak population in China. In addition,it is possible that HLA-DQA1*0103 has a role of protecting from essential hypertension.更多还原