【摘要】 目的:评估持续口服小剂量西地那非、佐洛复、百优解治疗早泄及停药后的疗效。方法:191例早泄病人随机归入3组,接受为期3个月的西地那非、佐洛复、百优解治疗。记录各组病人在治疗前、治疗后以及治疗停药2个月、3个月中国早泄指数评估表(CIPE)评分及性双方对性生活的满意程度。比较各组及组间在各阶段的CIPE评分。结果:3组对象治疗前CIPE分别为(20.77±2.77)、(20.92±2.80)和(20.98±2.53)分,差异无显著性(P>0.05);治疗3个月后分别为(39.22±4.56)、(37.53±3.76)和(37.66±3.63)分;停药2个月后为(31.24±5.25)、(22.85±5.67)和(22.47±4.64)分。停药3个月后西地那非组CIPE为(27.26±5.24)分。3组病人药物治疗3个月后CIPE较治疗前均有显著性升高(P<0.01)。组间除佐洛复组与百忧解组差异无显著性外,西地那非组与其它两组间差异均有显著性(P<0.05)。药物治疗后,3组对象夫妻性生活满意度明显改善,从高到低依次为:西地那非组、百忧解组、佐洛复组。西地那非组停药2个月后与治疗前CIPE差异有显著性(P<0.05);停药3个月后CIPE仍高于治疗前基线水平,41.5%病人仍具有较好疗效。佐洛复组及西地那非组停药2月后CIPE显著降低,大部分病人症状复发,退出研究,无法继续随访。结论:每日口服小剂量西地那非能有效治疗早泄。在效果上,好于左洛复和百忧解,每日口服小剂量西地那非在治疗停药后大部分病人疗效可达2个月以上。更多还原

【Abstract】 Objective:To evaluate the curative effects of low-dose Sildenafil,Sertraline and Fluoxetine for patients with premature ejaculation(PE),and to observe the effects in each treatment group after drug withdrawl.Methods:A total of 191 PE patients met our study criteria was divided randomly into three groups and then received 3-month treatment of Sildenafil,Sertraline and Fluoxetine,respectively.The curative effects in each group of patients before treatment,after treatment and after withdrawl of 2 months and 3 months using the methods of Chinese index of sexual function for premature ejaculation(CIPE) and the sex life satisfactory degree from both sides were recorded and compared.Results:Before treatment,there was no significant difference of CIPE among Sildenafil-group,Sertraline-group and Fluoxetine-group(20.77±2.77,20.92±2.80 and 20.98±2.53,respectively).After 3-month treatment,the CIPE was 39.22±4.56,37.53±3.76 and 37.66±3.63 respectively and 2 months after drug withdrawal,the CIPE was 31.24±5.25,22.85±5.67 and 22.47±4.64 respectively.There was positive difference of CIPE between pre-treatment and post treatment in each group(P <0.01).In addition,The significant difference between Sildenafil-group and other two groups after 3-month treatment was also observed.However,the differences between Sertraline-group and Fluoxetine-group could not be found.As to the sex life satisfactory degree,the patients of three groups all improved obviously after treatment,the results as follows:Sildenafil-group > Fluoxetine-group > Sertraline-group.Compared to other two groups,the Sildenafil-group patients still had effects in 3 months after drug withdrawal.Most patients,however,withdrew from the study because of recurrence after durg withdrawal.Conclusion:Low-dose Sildenafil is effective treatment for PE.The effect of Sildenafil is much better than Sertraline and Fluoxetine.Furthermore,the curative effect of Sildenafil can also maintain more than 2 months after drug withdraw among most PE patients.更多还原