【摘要】 特发性肺纤维化是一种病因不明的慢性进行性肺疾病,以纤维增殖、肺实质的破坏及细胞外基质的沉积为特征,其发病机制尚不明确。近几年的研究发现内源性气体信号分子(一氧化氮、一氧化碳和硫化氢)及调节肽(血管紧张素II、松弛素和尾加压素等)在调节肺纤维化,参与特发性肺纤维化的发病中发挥重要的作用。更多还原

【Abstract】 Idiopathic pulmonary fibrosis(IPF) is a chronic,progressive lung disease with unknown etiology and uncertain pathogenesis,characterized by fibroproliferation,destruction of the lung parenchyma and deposition of extracellular matrix.Recently,it was reported that endogenous gaseous transmitters(nitric oxide,carbon monoxide and hydrogen sulfide) and regulatory peptides(angiotensin II,relaxin and urotensin II et al) play a key role in regulating pulmonary fibrosis and may be critical to the pathogenesis and development of IPF.更多还原