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关联白噪声对抗肿瘤体系免疫效果的影响
Influence of correlated white noises on the immunity of an anti-tumor system
【摘要】 在免疫监视的Logistic肿瘤生长动力学模型中引入关联的乘性白噪声,并考虑抗肿瘤体系的免疫系统激活阈值存在差异,对上述动力学生长方程进行数值仿真计算.发现噪声关联强度能够调节抗肿瘤体系个体的免疫效果,但调节的结果存在差异;噪声关联强度λ的取值存在一个最佳区间,在该区间内更多的抗肿瘤体系个体能实现最大免疫效果.
【Abstract】 We introduced two correlated Gaussian multiplicative white noises into the Logistic growth model for an anti-tumor system subject to immune surveillance.Considering various active thresholds to initiate the immunity of the anti-tumor system,we made numerical simulations to investigate how the intensity λ of two correlated white noises influences the immune effect of an anti-tumor system.Our numerical results reveal that the correlation intensity λ has an optimal value,at which the anti-tumor system will achieve functionally the best immunity.
【关键词】 Logistic生长模型;
随机涨落;
肿瘤;
免疫;
【Key words】 Logistic growth model; stochastic fluctuation; tumor; immunity;
【Key words】 Logistic growth model; stochastic fluctuation; tumor; immunity;
【基金】 国家自然科学基金(批准号:30770629)资助的课题~~
- 【文献出处】 物理学报 ,Acta Physica Sinica , 编辑部邮箱 ,2009年01期
- 【分类号】O211.9
- 【被引频次】11
- 【下载频次】163