【摘要】 目的:探讨血清中癌胚抗原(CEA)、细胞角蛋白19片段(CYFRA21-1)、神经元特异性烯醇化酶(NSE)联合检测对肺癌的临床诊断价值.方法:采用电化学发光法分别检测30例肺癌患者和30例肺良性疾病患者血清中CEA、CYFRA21-1、NSE的含量.结果:肺癌组血清CEA、CYFRA21-l、NSE的含量显著高于肺良性疾病组,差异有统计学意义(P<0.01);CEA、CYFRA21-l、NSE联合检测阳性的敏感性(70.0%)最高,优于单项检测.结论:血清CEA、CYFRA21-1、NSE联合检测可提高肺癌诊断的敏感性,有助于对肺癌的早期诊断.更多还原

【Abstract】 Objective:To evaluate the clinical diagnosis value of combined detection of serum CEA、CYFRA21-1、and NSE in patients with lung cancer. Methods:Serum CEA、CYFRA21-1、 and NSE levels were determined by electro-chemiluminescence immunoassay in 30 patients with lung cancer,30 patients with benign pulmonary diseases. Results:The serum levels of CEA、 CYFRA21-1、and NSE in patients with lung cancer were significantly higher than those with benign lung diseases(P < 0.01). The positive rate of combined detection of serum CEA、CYFRA21-1、 and NSE in patients with lung cancer were significantly higher than that of serum CEA、CYFRA21-1、 and NSE levels ,separately. Conclusion:Combined determination of serum levels of CEA、 CYFR21-1、and NSE in lung cancers is helpful to improving the sensitivity and specificity in early diagnosis.更多还原