【摘要】 目的探讨内科治疗无效慢性胃炎的临床特征及有效治疗方案。方法将64例内科治疗无效的慢性胃炎设定为研究组与48例内科治疗有效的慢性胃炎设定为对照组,并对两组进行EPQ、HAMD、HAMA分值、治疗6周时IL-6、TNF-α测定对照,抑郁、焦虑分值与慢性胃炎症状严重度相关分析。同时再将研究组随机分为A、B两组,每组各32例,A组给予抗抑郁抗焦虑治疗,B组给予抗抑郁抗焦虑药物联合非典型抗精神病药物治疗。对A、B两组治疗前后进行SCL-90测定。结果研究组存在明显的神经质性人格,多为内向不稳定型,并伴有明显的焦虑抑郁情绪,抑郁焦虑分值与慢性胃炎症状的严重度呈正相关(r=0.59,F=54.98;r=0.86,F=339.98),治疗6周时两组IL-6、TNF-α比较具有显著差异,A、B两组治疗前后SCL-90的躯体化、焦虑、抑郁、恐怖因子分自身对照均有显著性差异,但两组比较则无显著差异。A组治疗前后偏执因子分无显著差异,而B组比较则有显著差异(2.24±0.81,1.15±0.61)。结论慢性胃炎的症状与人格、抑郁焦虑情绪、免疫功能密切相关,抗抑郁抗焦虑药物及其联合非典型抗精神病药物治疗均可改善慢性胃炎症状,但后者可改变患者的优势观念。更多还原

【Abstract】 Objective To search the clinic characteritics and the valid for the chronic gastritis wihich were treated by internal medicine without any effection.Methods 64 cases of patients contracted the chronic gastritis which were treated by internal medicine without any effection were set as a researching group;48 cases of patients contracted the chronic gastritis which were treated by internal medicine with valid effection were set as a comparison group.Confirmed the credits of EPQ,HAMD and HAMA.When treated 6 weeks,tested and compared IL-6 and TNF-α,analysed the relationship between the credit of depression/anxiety and the severity of the chronic gastritis symptom.At one time the researching group was divided A group and B,32 cases of patients for each.A group was treated with the antidepressant/antianxiety medicament only,B group was treated with the antidepressant/antianxiety medicament and the non-typical medication to resist the psychosis.Before and after treatment,tested SCL-90 of A group and B.Result There was obvious nervous personaliy in the researching group,the major portion of them belonged to the instable introversion type with a distinct anxious emotion.The credits of depression/anxiety were positive correlation with the severity of the chronic gastritis symptom.When treated 6 weeks,IL-6、TNF-α of the 2 groups were obvious different.Before and after treatment,SCL-90’s were distinct various in the somatization,anxiety,depression and terror factors compared with themselves in A group and B,but without obvious different between the 2 groups.The crankiness factor credit was obvious different in A group before and after treatment,but without obvious different in B group.Conclusion The chronic gastritis symptom has some close relationships with personality,depression/anxiety emotion and immunity factor.Antidepressant/anti-anxiety medicament with the treatment of the non-typical medication to resist the psychosis shall improve the depression/anxiety emotion,but the later shall change the predominance concept of the patients.更多还原