【摘要】 铁在ATP合成、氧的转运与利用等许多生理过程中发挥重要作用。骨骼肌是机体运动中利用铁的重要器官,运动会改变骨骼肌细胞的铁稳态,骨骼肌铁缺乏或铁超载都会影响骨骼肌细胞的功能,进而影响机体的运动能力。因此运动与铁代谢的关系引起越来越多学者的关注。骨骼肌细胞膜上铁转运蛋白受体1(transferrin receptor 1,TfR1)、二价金属离子转运体1(divalent metal transporter l,DMT1)、膜铁转运蛋白1(ferroportin 1,FPN1)等参与了铁的摄取和释放,NO可能对运动中骨骼肌铁代谢起重要调控作用,但其具体分子机制尚需深入研究。此外,骨骼肌细胞膜上分布着参与调节肠铁吸收的铁调素调节蛋白(hemojuvelin,HJV),其在运动中对肠铁吸收的调控作用有待进一步明确。更多还原

【Abstract】 Iron plays an important role in many physiological processes,such as ATP synthesis as well as oxygen transportation and utilization.Skeletal muscle is an important organ that utilizes iron during body movement.Movement will change the stability of iron in skeletal muscle cells.The deficiency or overload of iron in skeletal muscle cells will affect the functioning of skeletal muscle cells,thus affecting the body’s moving abilities.There-fore,the relation between movement and iron metabolism has caught the attention of more and more scholars.Transferrin receptors on skeletal muscle cell membrane,divalent metallic ion transporters,and ferroportins,have participated in iron intake and release.NO may play an important role in regulating iron metabolism of skeletal muscle in motion,but its special molecular mechanism needs for further study.In addition,hemojuvelin,which par-ticipates in iron absorption by intestines,is distributed on skeletal muscle cell membrane,its functions on regulating iron absorption by intestines in motion need to be further specified.更多还原