【摘要】 目前,溶瘤腺病毒治疗肿瘤的研究发展非常迅速,虽然有些溶瘤腺病毒进入临床试验阶段,并取得一定疗效,但其有效性和安全性仍是临床医生所担心的问题。本工作就此对溶瘤腺病毒的研究现状及如何更有效提高溶瘤腺病毒的杀伤作用进行分析,提出了用放射性核素标记溶瘤腺病毒,以期达到溶瘤治疗和核素治疗相结合,双重杀伤肿瘤细胞的目的。更多还原

【Abstract】 The research of oncolytic adenoviruses in tumor therapy is developed rapidly.Although some adenoviruses have been used in clinical trials and bring about therapeutic effect,the killing efficiency and safety have always been worried.So,the recent developments of oncolytic adenoviruses killing tumor cells were summarized and the way for enhancing the killing efficiency of oncolytic adenoviruses were discussed.Based on this discussion and the function of radionuclides,the idea that oncolytic adenoviruses labeled with radionuclides could combine oncolytic therapy and radiotherapy was put forword.更多还原