【摘要】 目的研究氨肽酶N抑制剂在肿瘤、癌症治疗中的作用。方法以噻吩、DMF为原料,合成2,5-噻吩二甲醛,进而合成了一系列噻吩衍生物类氨肽酶N抑制剂,并通过初步的氨肽酶活性测试。结果筛选出四种具有开发潜力的化合物。结论活性实验显示出化合物结构与活性之间存在内在关系,预计其在体内也应具有很好的抗肿瘤活性。更多还原

【Abstract】 Objective: To study the role of APN in tumor and cancer therapy.Methods: A series of thiophene derivate APN inhibitors was prepared with 2,5-thiophenedialdehyde,which was prepared with thiophene and DMF and their biological activity was tested.Results: The four compounds that had potential activities were selected.Conclusion: Biological activity tests show a relationship between the structure and activity of these compounds,and a good anti-tumor activity in bodies can also be expected.更多还原