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内生链霉菌Streptomyces sp.Ly221的次生代谢成分(英文)

Metabolites from Endophytic Streptomyces sp.Ly221

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【作者】 魏国柱王浩鑫李刚沈月毛赵沛基

【Author】 WEI Guo-zhu1,2,WANG Hao-xin1,2,LI Gang3,SHEN Yue-mao1,ZHAO Pei-ji11The State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650204,China;2Graduate University of the Chinese Academy of Sciences,Beijing 100039,China;3Yunnan College of Traditional Chinese Medicine,Kunming 650011,China

【机构】 中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室中国科学院研究生院云南中医学院

【摘要】 从云南美登木茎皮组织分离得到内生菌Ly221,经16S rDNA部分核酸序列鉴定该菌属于链霉菌属(Streptomyces)。从其液体发酵提取物中分离得到5个化合物,经波谱分析鉴定其结构分别为:4,10-dihydroxy-10-methyl-dodec-2-en-1,4-olide(1)、两个非对映异构体4,11-dihydroxy-10-methyldodec-2-en-1,4-olides(2/3)、4-hy-droxy-10-methyl-11-oxo-dodec-2-en-1,4-olide(4)和N-acetyltyramine(5)。

【Abstract】 The strain Ly221 was isolated from the branch tissue of Maytenus hookeri and determined to be a member of Streptomyces according to the 16S rDNA sequence.The extracts from the fermentation broth of Streptomyces sp.Ly221 were purified,and five compounds were obtained.They were identified to be 4,10-dihydroxy-10-methyl-dodec-2-en-1,4-olide(1),two diastereomeric 4,11-dihydroxy-10-methyldodec-2-en-1,4-olides(2/3),4-hydroxy-10-methyl-11-oxo-dodec-2-en-1,4-olide(4) and N-acetyltyramine(5) based on spectral data,respectively.

【关键词】 内生菌云南美登木烯丁酸内酯
【Key words】 endophytesMaytenus hookeributenolides
【基金】 supported by the Natural Science Foundation of Yunnan Province(2007C096M)
  • 【文献出处】 天然产物研究与开发 ,Natural Product Research and Development , 编辑部邮箱 ,2009年05期
  • 【分类号】Q936
  • 【被引频次】4
  • 【下载频次】187
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