【摘要】 目的观察不同剂量水杨酸钠(sodiumsalicylate,NaSA)对抗顺铂(cisplatin,CDDP)所致听损伤的作用。方法60只健康成年豚鼠随机分为4组,每组15只。分别为:Ⅰ组:CDDP+NaSA(50 mg/kg)、Ⅱ组:CDDP+NaSA(100 mg/kg)、Ⅲ组:CDDP+NaSA(150 mg/kg)、Ⅳ组(对照组):CDDP+生理盐水(NS)组。观察用药前后各组听性脑干反应(auditory brainstemresponse,ABR)阈值及畸变产物耳声发射(DPOAE)幅值的变化。结果用药后Ⅰ、Ⅱ、Ⅲ组与Ⅳ组相比,Ⅳ组ABR阈值升高较其他3组明显,差异有显著统计学意义(P<0.05)。Ⅰ、Ⅲ组分别与Ⅱ组相比,ABR阈值差异无显著统计学意义(P>0.05),而Ⅰ组ABR阈值明显高于Ⅲ组(P<0.05)。Ⅰ、Ⅱ、Ⅲ组在1、2、3、4、6、8 kHz各频率DPOAE幅值明显大于Ⅳ组(1、3 kHz,P<0.05;2、4、6、8 kHz,P<0.01)。结论水杨酸钠对顺铂所致的听损伤具有明显拮抗作用。更多还原

【Abstract】 Objective To investigate the antagonist effects of sodium salicylate(NaSA) on the cisplatin(CDDP) induced hearing impairment in guinea pigs.Methods 60 guinea pigs were randomly divided into four groups: ①CDDP +NaSA(50 mg/kg) group,②CDDP +NaSA(100 mg/kg) group,③CDDP +NaSA(150 mg/kg) group and ④CDDP +NS(normal saline) control group.Auditory brainstem response(ABR) and distortion product otoacoustic emission(DPOAE) were used to evaluate their effects on hearing threshold and DPOAE amplitudes.Results The ABR responses of groupsⅠ,Ⅱ and Ⅲ were significantly lower than in the control group(P<0.01) while they were insignificantly different in group Ⅱ from the other two groups(P>0.05).The ABR responses for group Ⅰ were significantly higher than group Ⅲ(P<0.05).The amplitudes of DPOAE at 1,2,3,4,6 and 8 kHz in group Ⅰ,Ⅱ and Ⅲ were greater than those in the control group(1,3 kHz,P<0.05;2,4,6,8 kHz,P<0.01).Conclusion Sodium salicylate can effectively reduce ototoxicity of cisplatin.更多还原