【摘要】 目的:制备心肌内生物可降解性支架,优化支架制备方式,评估其保持心肌孔道通畅的可行性。方法:以聚己内酯(PCL)为材料,聚乳酸-聚乙醇酸共聚物(PLGA)为药物载体,分别通过静电纺丝法、溶液浇注-溶剂挥发法和熔融挤出法制备成生物可降解性支架。采用万能材料测定仪测定支架的力学性能,制备猪慢性心肌局部缺血模型,在体评估该支架在透室壁性心肌血运重建术(TMR)后对心肌孔道的作用效果。结果:熔融挤出法制备的PCL支架具有较好的力学性能,支架压缩80%时承受的应力为1.7MPa,在TMR后可保持心肌孔道通畅。结论:成功制备出了心肌内生物可降解性药物缓释支架,熔融挤出法制备出的支架能承受心肌压力,可维持TMR后的心肌孔道通畅。更多还原

【Abstract】 Objective:To prepare biodegradable stents for transmyocardial revascularization (TMR),optimize the preparative method of stent,and evaluate its feasibility on myocardium channel after TMR. Methods:The stents were prepared using poly (ε-caprolactone)(PCL) and poly(D,L-lactide-co-glycolide) (PLGA) with electrospinning,solution spraying or melting extrusion. The mechanical strength of stent was tested by universal material testing machines. The effect of stent on myocardium channel after TMR was evaluated in vivo by a standard animal model of chronic myocardial ischemia in mini swine. Results:The stent showed the beneficial mechanical property by melting extrusion. The stent diminished 80% of initial scale under the stress of 1.7 MPa. The myocardium channel can be kept patency after TMR. Conclusion:A biodegradable stent in myocardium channel was prepared successfully,which can sustain the pressure from the heart. The stent can ensure the myocardium channel patency after TMR.更多还原