【摘要】 目的:研究平滑肌肉瘤中是否存在血管生成拟态,阐述血管生成拟态的临床意义及相关机制。方法:收集临床和预后资料完整的平滑肌肉瘤组织切片45例,复习切片明确诊断后进行CD34和PAS双重染色,证实肿瘤组织中血管生成拟态的结构,分析血管生成拟态相关的临床意义。结果:45例平滑肌肉瘤中25例(55.6%)具有血管生成拟态。有转移患者和无转移患者血管生成拟态阳性率差别有统计学意义(P<0.05),生存的患者和死亡的患者血管生成拟态阳性率差别也有统计学意义(P<0.01)。Kaplan-Meier生存分析提示有无血管生成拟态肿瘤患者生存时间差异有统计学意义(P<0.05)。结论:平滑肌肉瘤中存在血管生成拟态,血管生成拟态是平滑肌肉瘤患者预后的不利因素,有血管生成拟态的患者易发生转移,预后比无血管生成拟态的患者差。更多还原

【Abstract】 Objective: To observe the existence of vasculogenic mimicry in leiomyosarcoma and the clinical significance and mechanism thereof. Methods: The clinical and pathological data of forty-five cases of leiomyosarcoma were collected in the study. The presence of vasculogenic mimicry was observed by immunohistochemical and histochemical double staining of CD34 and PAS. The clinical significance of vasculogenic mimicry was assessed.Results: Vasculogenic mimicry channels were found in 25 of the 45 leiomyosarcoma cases (55.6%). There was a statistical significance between the cases with and without metastasis(P < 0.05). There was also a statistical significance between survival group and dead group (P < 0.01). Kaplan-Meier survival analysis showed the presence of vasculogenic mimicry channels had a negative influence on the prognosis (P < 0.05). Conclusion: The vasculogenic mimicry exists in leiomyosarcoma, which is an unfavorable factor influencing prognosis of the patients with leiomyosarcoma. The patients with vasculogenic mimicry channels in the tumor are prone to suffer the metastasis. Prognosis for patients with vasculogenic mimicry channels in leiomyosarcoma is poorer than that in patients without vasculogenic mimicry.更多还原