【摘要】 目的:探讨中国汉族人群系统性红斑狼疮(SLE)与HLA-DQB1基因的关联情况。方法:检索已发表的有关中国汉族人群SLE和HLA-DQB1关联研究的文献,剔除不符合要求的文献,应用Revman4.1软件进行一致性检验和数据合并。结果:等位基因DQB1*0502、DQB1*0601可能是中国汉族人群SLE患者的危险基因(P<0.05);等位基因DQB1*0301、DQB1*0302和DQB1*0401可能是中国汉族人群SLE患者的保护基因(均P<0.05)。结论:中国汉族人群SLE与HLA-DQB1的某些等位基因具有关联性,且与其他种族人群有差异。更多还原

【Abstract】 Objective:To explore the association between systemic lupus erythematosus (SLE) with HLA-DQB1 in Chinese population. Methods: The reported articles about SLE in Chinese population and HLA-DQB1 were searched and the meta-analysis via Revman4.1 was performed. Results: DQB1*0502 and DQB1*0601 might be the risky alleles (all P<0.05) in Chinese population. DQB1*0301, DQB1*0302 and DQB1*0401 might be the protective alleles (all P<0.05). Conclusion: In Chinese population , some HLA–DQB1 alleles are associated with the SLE, and these associations are different from those in other populations.更多还原