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1,4-二脂肪氨基-5,8-二羟基蒽醌的合成及抗癌活性研究
Synthesis,characterization and anticancer activity of 1,4-bialiphatic amino-5,8-dihydroxy anthraquinones
【摘要】 合成抗癌药物中间体脂肪胺取代的蒽醌类化合物,并对其进行体外抗癌活性测试.以1,4,5,8-四羟基蒽醌隐色体和脂肪胺为原料,在氮气保护下进行缩合反应,然后通过氧化合成目标化合物.对目标化合物利用红外光谱和核磁共振氢谱进行表征.体外抗癌活性测试表明化合物1,4-二[2-(二甲氨基)-乙氨基]-5,8-二羟基蒽醌有较强的抗癌活性.
【Abstract】 1,4-Bialiphatic amino-5,8-dihydroxy anthraquinones as an intermediate of an anticancer drug were synthesized by the condensation and oxidation of leuco-1,4,5,8-tetrahydroxyanthraquinone with aliphatic amine.Their structures were determined by FTIR and 1H-NMR analysis.Anti-cancer activities of these compounds were roughly tested in vitro.Such 1,4-bi[2(dimethylamio)-ethylamino]-5,8-dihydroxy-anthraquinone derivates made this a versatile strategy for the lead compound of anti-tumor drug.
【关键词】 1,4,5,8-四羟基蒽醌隐色体；
抗癌药物；
药物合成；
脂肪胺；
【Key words】 leuco-1,4,5,8-tetrahydroxyanthraquinone； antitumor drug； chemical synthesis； aliphatic amine；
【Key words】 leuco-1,4,5,8-tetrahydroxyanthraquinone； antitumor drug； chemical synthesis； aliphatic amine；
【基金】 国家自然科学基金(20376063);天津市自然科学基金(043610511)
- 【文献出处】 天津理工大学学报 ,Journal of Tianjin University of Technology , 编辑部邮箱 ,2009年02期
- 【分类号】R914;R730.5
- 【下载频次】243