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酸枣仁提取物急性毒性实验研究

Study on Acute Toxicity of Alcohol-soluble Extract of Semen Ziziphi Spinosae

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【作者】 王丽娟张明春闫超

【Author】 WANG Li-juan1,2,ZHANG Ming-chun1,2,YAN Chao2(1.Tianjin Key Laboratory of Food Technology,Tianjin 300134,China;2.Department of Pharmaceutic Project,School of Biotechnology and Food Science,Tianjin Commerce University,Tianjin 300134,China)

【机构】 天津市食品生物技术重点实验室天津商业大学生物技术与食品科学学院

【摘要】 目的观察酸枣仁醇提取物的急性毒性反应。方法①小鼠尾静脉注射不同剂量的酸枣仁醇提取物,连续观察14d,记录小鼠的急性毒性反应,并计算LD50及LD5095%可信限;②小鼠灌胃给药,测定一次给予酸枣仁醇提取物的安全剂量。结果①静脉注射酸枣仁醇提取物后,部分小鼠出现中毒反应并死亡,测得LD50为27.5g·kg-1,LD5095%可信限为25.1~30.1g·kg-1,死亡动物尸检,其主要脏器未见病理改变。14d后存活小鼠体重平均增加20.4%,略高于生理盐水组(18.2%)。②小鼠灌胃给药(340g·kg-1,相当于成人一次用量的326倍)后,连续观察14d,小鼠全部存活,无明显毒性反应,小鼠体重平均增长17.2%。结论酸枣仁醇提取物毒性很低,临床给药安全可靠。

【Abstract】 Objective To observe the acute toxic reaction of alcohol-soluble extract of Semen Ziziphi Spinosae(SZS)in mice.Methods ①Alcohol-soluble extract of SZS was intravenously injected and observed for consecutive 14 days.The acute toxic reaction was recorded and the LD50 and 95% confidence limit of LD50 were calcucated.②By ig administration in mice,the acute toxic reaction was observed and the safety dosage was assayed.Results After intravenous injection,partial mice showed toxic reaction and death.The LD50 was 27.5 g·kg-1,its 95% confidence limit was 25.1~30.1 g·kg-1,its average confidence limit was(27.5±2.4)g·kg-1.After ig administration,all mice survived,and no toxic reaction was shown in observed period.The average rate of its increasing weight was 17.2%.The dosage was 326 g·kg-1,equivalent to men’s dose by 340 times.Conclusion SZS is safe for clinical administration.

【基金】 天津市科委科技支撑计划重点项目(No.07ZCKFNC00300)
  • 【文献出处】 时珍国医国药 ,Lishizhen Medicine and Materia Medica Research , 编辑部邮箱 ,2009年07期
  • 【分类号】R285.5
  • 【被引频次】14
  • 【下载频次】755
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