【摘要】 目的制备羟基喜树碱的半固体脂质纳米粒(HCPT-SSLN)。方法在单因素考察的基础上,通过正交设计优选处方和制备工艺,并对优化条件下制备的HCPT-SSLN纳米溶液进行质量评价。结果制备的HCPT-SSLN平均粒径为130.5 nm,多分散系数为0.18,载药量为2.51%,包封率为79.19%,ξ电位为-33.1mV;纳米溶液4℃下放置6个月,纳米粒外观、粒径及包封率无明显变化。结论所制备的HCPT-SSLN包封率和载药量较高,粒径分布均匀,稳定性良好,为羟基喜树碱的临床应用提供了更广阔的前景。更多还原

【Abstract】 Objective To prepare hydroxycamptothecin semisolid lipid nanoparticles(HCPT-SSLN).Methods Based on the single-factor experiment,the HCPT-SSLN was prepared by orthogonal design for optimization of formulation and technology.Then the obtained SSLN was evaluated.Results The mean particle size of the prepared HCPT-SSLN was 130.5nm,Polydispersity index(PI) was 0.18,drug loading(DL) was 2.51%,entrapment efficiency(EE) was 79.19%,ξ potential was-33.1mV;Placed at 4℃ for 6 months,the appearance,particle size and entrapment efficiency of SSLN were all stable.Conclusion The HCPT-SSLN has high entrapment efficiency and drug loading,uniform particle size,good stability,which provides an extensive prospect for clinical application of HCPT.更多还原