【摘要】 目的探讨糖耐量受损患者血清胱抑素C(S-cysC)检测对早期肾损害的意义。方法根据糖耐量试验(OGTT)结果选择研究对象:糖调节正常组(NGT)63例;空腹血糖受损组(IFG)41例;糖耐量受损组(IGT)49例。分别检测其S-cysC和尿微量白蛋白(u-mAlB)。结果IFG组与NGT组比较:S-cysC(0.96±0.15)vs(0.91±0.14)mg/L(P>0.05);u-mAlB(14.7±2.9)vs(13.5±3.5)mg/24h(P>0.05)。IGT组与NGT组比较:S-cysC(1.41±0.56)vs(0.91±0.14)mg/L(P<0.01);u-mAlB(15.4±4.3)vs(13.5±3.5)mg/24h(P<0.05)。IGT组S-cysC与u-mAlB异常率比较:30.6%vs12.2%(P<0.01)。结论IGT患者可引起肾损害,CysC是早期肾损害的敏感指标,对IGT患者肾损害诊断有重要参考价值。更多还原

【Abstract】 Objective To study the value of serum cystatin C(S-cysC)in diagnosis of early renal damage in patients with impaired glucose tolerance.Methods According to the results of oral glucose tolerance test(OGTT),the patients were divided into normal glucose tolerance(NGT)group(n=63),impaired fasting glucose(IFG)group(n=41),and impaired glucose tolerance(IGT)group(n=49).The levels of S-cysC and urinary microalbumin(u-mAlB)were determined respectively.Results The levels of S-cysC and u-mAlB in IFG group and NGT group:S-cysC(0.96±0.15)vs(0.91±0.14)mg/L,P>0.05;u-mAlB(14.7±2.9)vs(13.5±3.5)mg/24h,P>0.05.The levels of S-cysC and u-mAlB in IGT group and NGT group:S-cysC(1.41±0.56)vs(0.91±0.14)mg/L,P<0.01;u-mAlB(15.4±4.3)vs(13.5±3.5)mg/24h,P<0.05.The abnormal rate of S-cysC and u-mAlB in IGT:30.6% vs 12.2%,P<0.01.Conclusions IGT can cause renal damage;CysC is a sensitive parameter in diagnosis of early renal damage in patients with IGT.更多还原