【摘要】 目的探讨急性有机磷农药中毒后迟发性多发性神经病的临床特点、发病机制,以提高早期诊断及治疗效果。方法回顾28例迟发性多发性神经病发生的时间、症状及体症,结合辅助检查,进行系统分析。结果28例迟发性多发性神经病患者均为口服中毒,潜伏期为10～32d,平均18d。主要表现为肢体末端开始的感觉和运动障碍,表现为疼痛、麻木、无力、肌肉萎缩、腱反射减弱或消失,肌电图示神经源性损害。用糖皮质激素、B族维生素等综合治疗,大部分预后良好。结论迟发性多发性神经病经早期诊断,积极治疗,预后一般良好,激素治疗可加速神经功能恢复。更多还原

【Abstract】 Objective To explore the clinical features and pathogenesis of the delayed polyneuropathy induced by acute organophosphorus pesticide poisoning,and improve the curative effects of early diagnosis and treatment.Methods The onset time,symptoms and physical signs of 28 cases of delayed polyneuropathy were recalled and analyzed combined with supplementary examination retrospectively.Results 28 delayed polyneuropathy were all oral poisoning,the incubation period was of 10 to 32 days,with an average of 18 days.Dyskinesia and abnormity of sense started from the end of limbs,such as pain,numbness,weakness,muscle atrophy,weakening or disappearance of tendon reflexes,neurogenic damage showed by electromyography,were the main clinical manifestation.The comprehensive treatment with glucocorticoid and B vitamins could improve prognosis.Conclusion The delayed polyneuropathy has a good prognosis by early diagnosis and active treatment,and hormone therapy may accelerate the recovery of neurological function.更多还原