【摘要】 目的了解性病门诊生殖器念珠菌病的易感因素、致病菌及对抗真菌药物的敏感性。方法收集疑似病例,通过真菌学确诊后进行流行病学调查,并进行菌种鉴定和体外药敏试验。结果168例疑似患者共分离培养出念珠菌46株(白念珠菌44株占95.6%、克柔念珠菌1株、光滑念珠菌1株);配偶/性伴患病、广谱抗菌素的应用等与本病相关;对抗真菌药的敏感性分别为酮康唑(KCZ)97.7%、伊曲康唑(ICZ)84.1%、特比萘芬(TBF)63.6%、两性霉素B(AMB)88.6%、咪康唑(MCZ)93.2%、氟康唑(FCZ)95.5%、5-氟胞嘧啶(5-FC)90.9%;ICZ和KCZ对FCZ耐药株的最低抑菌浓度(MIC)值偏高。结论配偶/性伴患病是最主要的易感因素;致病菌以白念珠菌为主,唑类药物存在交叉耐药倾向。更多还原

【Abstract】 Objectivey To analyze the genital candidiasis predisposing factors,the pathogenic bacteria and antifungal drug sensitivity.Methodsy After collecting suspected genital candidiasis patients and taking microscopic examination of fungal spores,epidemiological investigation was made,pathogenic Candida had been identified and vitro antifungal susceptibility test was carried out.Resultsy There were 46 Monilia were isolated from 168 patients with genital candidiasis.Drug susceptibility rate to the antifungal agent respectively was KCZ 97%、ICZ 84.1%、TBF 63.6%、AMB 88.6%、MCZ 93.2%、FCZ 95.5%、5-FC 90.9%.Conclusion The main predisposing factor is mate or spouse with genital candidiasis.Candida albicans was the most important pathomycete.And the cross-resistance occurred in azoles.更多还原