【摘要】 目的探讨DNA修复蛋白O6-甲基鸟嘌呤-DNA甲基转移酶(MGMT)在老年食管癌患者的表达及临床意义。方法采用免疫组织化学方法检测57例食管癌标本和20例正常食管组织中MGMT的表达,并分析其与临床病理特征之间的关系。结果MGMT在食管癌表达的阳性率(49.1%)明显低于正常组织(85.0%,P<0.01)。侵及外膜层、有淋巴结转移、Ⅲ+Ⅳ期的食管癌患者MGMT阳性率明显低于未侵及外膜层、无淋巴结转移、Ⅰ+Ⅱ期患者(P<0.05)。MGMT在食管癌表达的阳性率在年龄、性别、分化程度、肿瘤部位组间无明显差异(P>0.05)。结论MGMT在食管癌的表达与浸润深度、淋巴结转移和临床分期有关,可作为判断食管癌预后的指标。更多还原

【Abstract】 Objective To explore the expression and clinical significance of MGMT in patients with esophageal carcinoma.Methods The expression of MGMT was detected by immunohistochemical techniques in 57 cases of esophageal carcinoma and 20 normal cases.The relationship of MGMT with clinical and pathological parameters was analyzed. Results The positive rate of MGMT expression in esophageal carcinoma was less than that in normal esophagus mucosa(P<0.01).The positive rate of MGMT expression in the esophageal carcinoma without ectoblast invasion,no lymph node metastasis or in stage Ⅲ+Ⅳ,was lower than that with ectoblast invasion,lymph node metastasis or in stage Ⅰ+Ⅱ(P<0.05).There was no significant difference in age,sex,differentiated grade and tumor position(P>0.05).Conclusions Expression of MGMT in esophageal carcinoma is related with tumor stage,lymph node metastasis and tumor stage.It may be used as an important marker to evaluate the prognosis of esophageal carcinoma.更多还原