【摘要】 目的 探讨肝纤维化和肝硬化病人磁化传递率(MTR)与血清学指标的相关性,以及对肝硬化早期诊断的价值。方法分别对44例肝纤维化病人、49例肝硬化病人及46例正常对照组利用磁共振磁化传递成像(MTI)进行检查,并对MTR与血清学指标对照,采用Kruskal Waills进行非参数统计分析,采用Pearson相关性检验及偏相关性检验进行相关性分析。结果 对照组、肝纤维化组、肝硬化组磁化传递率差别无统计学意义(H=3.558,P=0.169);肝纤维化组Pearson相关分析显示磁化传递率与透明质酸(HA)(r=0.724,P=0.000)和Ⅳ型胶原(r=0.425,P=0.038)正相关;偏相关显示磁化传递率仅与透明质酸(HA)相关(r=0.8748,P=0.000)。结论 磁化传递率可间接反映肝纤维化胶原沉积情况,MTI技术和透明质酸等血清学检查指标相结合,在预测肝纤维化和肝硬化等弥漫性病变的早期诊断中有一定价值。更多还原

【Abstract】 Objective To study relativity between magnetization transfer rate(MTR) and serum index in liver fibrosis and cirrhosis.Methods 44 patients with hepatic fibrosis,49 patients with cirrhosis and 46 control subjects underwent magnetization transfer imaging(MTI).The relativity of MTR and serum index in all cases were analysed with the Kruskal-waills to do the non-parameter statistic analysis,the Pearson correlation test and partial correlation test to do the correlation analysis.Results MTRs among control group,liver fibrosis and cirrhosis were no of statistical differences(H=3.558,P=0.169).Pearson analysis showed that MTR was of positive correlation with hyaluronic acid(HA)(r=0.724,P=0.000) and type Ⅳ collagen(r=0.425,P=0.038) in liver fibrosis.Conclusion Magnetization transfer rate is positive correlation with HA,which reflect the deposition of collagen and has certainly value for the early diagnosis of liver fibrosis and cirrhosis.更多还原