【摘要】 目的 探讨绝经后妇女骨密度与乳腺癌的易患性之间的相关性。方法 采用法国CHALLENGER公司双能X线骨密度仪,测定67例乳腺癌患者和67例同年龄段非乳腺癌患者的腰椎（L₂～L₄）及左髋部骨密度值。结果 （1）乳腺癌组患者初次妊娠年龄比对照组要晚,初潮年龄低于12岁的比例也比对照组要高,而且具有乳腺癌家族史和既往良性乳腺疾病的人数比例高于对照组,2组具有极显著差异（P<0.01）。（2）2组患者在腰椎、股骨颈、全髋关节的骨密度无显著性差异,P>0.05。（3）经年龄、BMI、乳腺癌家族史、绝经年龄及其它有可能引起乳癌的危险因素作多元校正后,对于各分布组间患乳腺癌的危险性（优势比）并无显著区别（P>0.05）。结论 乳腺癌是多因素引起的复杂性疾病。骨密度与乳腺癌的易患性之间不存在必然的相关性。更多还原

【Abstract】 Objective To study the relationship between bone mineral density(BMD) in postmenopausal women and breast cancer risk.Methods Using dual-energy X-ray absorptiometry,BMD in lumbar spine and left femur was measured in 67 women with breast cancer and 67 age-matched women without breast cancer.Results(1) In comparison to the control group,the women with breast cancer had significantly later age at first pregnancy,higher percentage in age at menarche below 12,family history of breast cancer and history of benign breast disease(P<0.01).(2) There were no significant differences between two groups for BMD in lumbar spine and left femur(P>0.05).(3) There were no significant differences in the risk of breast cancer by tertile of BMD at the total hip and femoral neck,and between women with osteoporosis or osteopenia and women with normal BMD for risk of breast cancer(P>0.05).Conclusion Breast cancer is a disease caused by multiple factors.There is no association between BMD and breast caner risk.更多还原