【摘要】 目的探讨动脉灌注联合手术治疗浅表性膀胱癌的临床疗效。方法42例浅表性膀胱癌患者随机分为A、B两组,每组21例,A组采用动脉灌注化疗加手术治疗、B组采用单纯手术治疗。结果42例随访16～32个月,平均29个月。A组患者经动脉灌注化疗后大部分膀胱病灶缩小,血尿缓解或消失,术后病理检查肿瘤细胞超微结构改变明显。A组术后复发3例(14.3%),死亡1例(4.8%)。B组术后复发10例(47.6%),死亡2例(9.5%)。A组术后复发率、死亡率低于B组(P<0.05)。两组比较化疗后副反应和并发症比较差异无统计学意义(P>0.05)。结论动脉灌注联合手术治疗浅表性膀胱癌疗效好,副反应少,临床应用安全可靠。更多还原

【Abstract】 Objective To investigate the value of combined interventional chemotherapy and surgical operation on superficial bladder cancer.Methods 42 patients with superficial bladder cancer were randomized into group A and group B. The patients in group A were treated with preoperative arterial infusion chemotherapy,while the patients in group B were treated by surgical operation alone.Results The patients have been followed up for 16～32 months(mean 29 months). Most patients in group A experienced a significant reduction in tumor volumes and a decrease of hematuria after chemotherapy. Significant ultrastructure changes were observed in pathological study. 3 patients (14.3%) had recurrent disease and 1 patients died (4.8%). 10 relapse (47.6%) and 2 death (9.5%) were seen in group B. Recurrence rate and death rate in group A were significantly lower than that in group B (P<0.05). The side-effect and complication rate showed no significant difference between 2 group(P>0.05).Conclusion Combined use of interventional chemotherapy and surgical operation is effective and safe in the treatment of patients with superficial bladder cancer.更多还原