【摘要】 目的:探讨结直肠肿瘤中Bcl-2和Caspase-3蛋白的表达及其临床意义。方法:取42例结直肠腺癌、10例正常结直肠黏膜组织,以免疫组化方法(S-P法)检测Bcl-2和Caspase-3蛋白的表达,分析其表达与结直肠腺癌临床病理特征的关系。结果:Bcl-2、Caspase-3在正常组织和大肠癌组织中的表达差异具有统计学意义(P<0.05);Bcl-2和Caspase-3与大肠癌分级有关(P<0.05),但与Dukes分期、淋巴结转移无关(P>0.05)。结论:腺癌组织中Bcl-2和Caspase-3可能参与了结直肠癌的发生、发展过程,对大肠癌及腺癌进行Bcl-2和Caspase-3基因检测有助于大肠癌的早期诊断及预后评估。更多还原

【Abstract】 Objective:To study the expression and significance of Bcl-2 and Caspase-3 in colorectal carcinoma.Methods:SP immunohistochemical technique was used to examine the expression of Bcl-2 and Caspase-3 in 42 cases of colorectal carcinoma and 25 cases of normal colorectal mucosa.Results:The expressions of Bcl-2 and Caspase-3 were significantly different in different pathological grading(P<0.05) and were no significantly different in stages of Dukes and lymphnode metastasis(P>0.05).Conclusion:The expressions of Bcl-2 and Caspase-3 may be closely correlated to the occurrence and development of colorectal carcinoma.Detecting the expression of Bcl-2 and Caspase-3 in colorectal carcinoma is useful for the early diagnosis of colorectal carcinoma and evaluation of the prognosis.更多还原