【摘要】 目的:研究基质金属蛋白酶-9(MMP-9)、潜伏膜蛋白-1(LMP-1)在鼻咽癌中的表达及其对鼻咽癌远处转移的影响。方法:收集83例鼻咽癌患者的临床资料及鼻咽部瘤体活检组织蜡块。采用免疫组化S-P法检测标本中MMP-9、LMP-1的表达。结果:MMP-9阳性表达率为65%(54/83),其表达与颈淋巴结转移、远处转移关系密切(P<0.05)。LMP-1阳性表达率为57%(47/83),其表达与颈淋巴结转移、远处转移关系密切(P<0.05);且与MMP-9表达呈显著正相关(rs=0.327,P<0.05)。鼻咽癌远处转移的危险因素是临床分期(Ⅲ、Ⅳ期)、颈淋巴结N3阳性、MMP-9阳性表达、LMP-1阳性表达(P<0.05)。MMP-9、LMP-1均为阳性表达者远处转移风险更高(P<0.05)。结论:MMP-9、LMP-1阳性表达与远处转移明显相关,可作为鼻咽癌远处转移的预测指标。更多还原

【Abstract】 Objective:To assess the relation of expression of matrix metalloproteinase-9(MMP-9) and latent membrane protein-1(LMP-1) with metastasis in nasopharyngeal carcinoma(NPC).Methods:The expressions of MMP-9 and LMP-1 were immunohistochemically examined in 83 NPC section.Results:The positive expression rate of MMP-9 was 65%,correlated with lymph node metastasis,distant metastasis(P<0.05).The positive expression rate of LMP-1 was 57%,correlated with lymph node metastasis,distant metastasis(P<0.05).The expression of MMP-9 showed a significant positive correction with the expression of LMP-1(r=0.327,P<0.05).The factor predicting distant metastasis in NPC was stage(Ⅲ、Ⅳ),N3,positive expression of MMP-9 and LMP-1.Conclusion:MMP-9 and LMP-1 are highly expressed in NPC,can be used as predictor of distant metastasis.更多还原