【摘要】 TSLC1是一种新的抑癌基因,其失活与消化系肿瘤的发生,浸润转移及预后有着重要的关系。TSLC1的失活重要机制之一是基因甲基化。TSLC1定位于11q23.2上,由胞外区,跨膜区和胞质区组成,其结构与抑癌功能有关。TSLC1的抑癌机制目前还不完全明确,认为与细胞黏附,细胞间信号传导,参与肿瘤免疫,诱导细胞凋亡和抑制细胞生长周期有关。更多还原

【Abstract】 TSLC1 is a novel anti-oncogene,its deactivation correlates with the carcinogenesis,inasion,metastasis of digestive tract tumor and the prognosis of the patients closely.One of inactivation mechanisms of TSLC1 is methylation of gene.TSLC1 locates in 11q23.2 and composes of extracellular region,transmembrane domain and cytomere.Its architectonic correlates with the function of anticancer.The anticancer mechanism is still undefined presently,but correlates with cell adhesion,signal transmission of cells,tumor immunity,apoptosis and inhibition of cell growth cycle.更多还原