【摘要】 目的:探讨有下尿路症状(LUTS)的前列腺增生(BPH)人群年龄、前列腺体积、残余尿、国际前列腺症状评分(IPSS)、最大尿流率对血清前列腺特异性抗原(PSA)值的影响,寻找影响血清PSA值的最主要因素。方法:应用酶联免疫法测定了191例51～81岁有LUTS的BPH人群血清总前列腺特异性抗原(TPSA)、游离前列腺特异性抗原(FPSA)值。应用直线相关统计学方法分析年龄、前列腺体积、残余尿、IPSS评分、最大尿流率与血清PSA值的相关性。结果:年龄与TPSA、FPSA、前列腺特异抗原密度(PSAD)成正相关关系(P<0.05);与FPSA/TPSA无相关性(P>0.05)。前列腺体积与TPSA、FPSA呈强正相关关系(P<0.01);与FPSA/TPSA值呈弱负相关关系(P<0.05)。残余尿量、IPSS评分与血清TPSA值呈弱正相关关系(P<0.05)。最大尿流率和血清TPSA值有弱负相关关系(P<0.05)。多元线性回归分析得出只有前列腺体积与血清PSA值有相关性(P<0.01),其他因素与血清PSA值之间均没有相关性(P>0.05)。结论:前列腺体积是导致血清PSA值变化的最主要因素。更多还原

【Abstract】 Objective:To evaluate the relationship between age,prostate volume,post-void residual urine,flow rate,international prostatic symptom score and serum prostatic specific antigen,and explore the most affected reason on serum PSA.Methods:Serum tPSA and fPSA were measured by enzyme linked immunosorbent assay(ELISA) in 191 BPH patients of 23～85 years old with LUTS The relationship between age,PV,PVR,IPSS,Qmax and PSA indexes was analyzed with simple linear regression1.Results:Age and tPSA,fPSA,PSAD had a positive liner relationship(P<0.05);age had no correlation with FPSA /TPSA(P>0.05).PV had strong positive correlation with TPSA and FPSA(P<0.01);there was weak negative correlation between PV and F/T(P<0.05).PVR and IPSS had weak positive correlation with tPSA.There was weak negative correlation between Qmax and tPSA(P<0.05).Multiple linear regession analyses showed that only PV had correlation with PSA(P<0.01).Conclusion:The PV might be the principal reason of PSA increase.更多还原