【摘要】 目的研究大黄对创伤失血性休克(T/HS)患者肠功能障碍患者的治疗作用。方法T/HS肠功能障碍98例,随机分成两组:治疗组(45例),应用生大黄10 g,每日2次胃管注入;对照组(53例)除不应用生大黄外,原发病及其他治疗与治疗组一致。观察两组患者肠功能障碍的恢复率、恢复时间及多器官功能障碍综合征(MODS)的发生率、病死率等。结果治疗组的肠功能障碍恢复率高于对照组(82%和36%),肠功能障碍的持续时间低于对照组[(1.5±1.2)d,(5.8±3.0)d],MODS发生率低于对照组(27%和70%),两组比较差异具有统计学意义(P<0.05)。MODS的病死率分别为17%和29%,治疗组病死率低于对照组,两组比较差异无统计学意义。结论大黄对T/HS患者肠功能障碍具有较好的治疗作用,可以明显降低MODS的发生率和病死率。更多还原

【Abstract】 Objective To study the effects of rhubarb on gut dysfunction of trauma/hemorrhagic shock(T/HS) patients.Methods Ninety-eight patients with T/HS gut dysfunction were divided into 2 groups randomly: the treat ment group(n=45),treated with rhubarb,and the control group(n=53),the therapy unanimous with treat group excluding treat with rhubarb.The alleviative rate and time of gut dysfunction,morbidity and mortality of MODS in 2 groups were observed.Results In the treat ment group,the alleviative rate of gut dysfunction was higher than that of the control group(82% vs 36%);the continuance of gut dysfunction was shorter than that of the control group [(1.5±1.2)d,vs(5.8±3.0)d];the morbidity of MODS was lower than tnat of the control group(27% vs 70%).There was statistical difference between two groups(P<0.05).The mortality of MODS in treat ment group was lower than tnat of the control group(17% vs 29%),though there were no statistical differences between two groups,the mortality of treat group was lower than that of the control group.Conclusion Rhubarb has the therapeutic effect on gut dysfunction of T/HS and reduces the morbidity and mortality of MODS.更多还原