【摘要】 目的:比较大剂量辛伐他汀与一般剂量辛伐他汀在急性心肌梗死治疗中的疗效和安全性。方法:483例急性心肌梗死患者,随机分为治疗组:245例,辛伐他汀60mg/d,持续3个月;对照组:238例,辛伐他汀20mg/d,持续3个月。观察血脂、高敏C反应蛋白、肝功能、心肌钙、心血管事件及再次住院率等指标。结果:治疗组在血脂、高敏C反应蛋白下降、心血管事件及再次住院率与对照组差异有统计学意义(P<0.05)。结论:大剂量辛伐他汀在定期监测肝功能情况下使用能更好地降低心梗患者的血脂、炎性反应从而减少心血管事件及再次住院率。更多还原

【Abstract】 Objective:To investigate the efficacy and safe-ty of Simvastatin with two different doses in treating acute myo-cardial infarction.Methods:483 patients with AMI were randomly divided into two groups.They were treated with Simvastatin 20mg and 60mg a day respectively and were followed up for 30 days.The effect of Simvastatin with two different doses on serum lipid,the serum level of high sensitivity C reactive protein(hs-CRP),he-patic function,myocardial calcium,incidence of cardiac vascular events and hospitalization rate were observed.Results:During the 30 days following up,serum lipid,the serum level of high sensi-tivity C reactive protein(hs-CRP),incidence of cardiac vascular events and hospitalization rate in 60mg group was significantly lower than that in 20mg group (P<0.05).Conclusion:The efficacy of 60mg Simvastatin is superior to that of 20mg Simvastatin in de-creasing the serum levels of in?ammatory factors,serum lipid,the incidence of cardiac vascular events and hospitalization rate.更多还原