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R-(+)硫-代四氢呋喃-2-甲酸的合成
The synthesis of R-(+)-thiotetrahydrofuran-2-carboxylic acid
【摘要】 以R-(+四)-氢呋喃-2-甲酸为原料,通过草酰氯酰化,与NaHS发生取代反应,合成R-(+)硫-代四氢呋喃-2甲-酸,粗品经柱层析,减压蒸馏纯化。产品收率53.3%,产物结构经MS,1H NMR确认。
【Abstract】 R-(+)-thiotetrahydrofuran-2-carboxylic acid was synthesized via R-(+)-tetrahydrofuran-2-carboxylic acid by acylation using oxalyl chloride followed by step of substitution reaction using sodium hydrosulfide.The crude product was purified by chromatography column and vacuum distillation.The overall yield was 53.3% and the products was confirmed by MS and 1H NMR.
- 【文献出处】 应用化工 ,Applied Chemical Industry , 编辑部邮箱 ,2009年12期
- 【分类号】TQ251.1
- 【被引频次】2
- 【下载频次】143