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β-环糊精包结维生素A醋酸酯的条件研究
Study on the synthesis of the inclusion complex of vitamin A acetate with β-cyclodextrin
【摘要】 研究了β-环糊精与维生素A醋酸酯的包结,探讨了客体添加速度、溶剂、温度等对包结物产率的影响。25℃下,往1 g的β-环糊精水溶液(60 mL)中滴加0.289 0 g的维生素A醋酸酯乙醇溶液(6 mL),滴加时间70 min,搅拌10 h,包结率可达78.0%。利用分子模拟软件模拟了β-环糊精与维生素A醋酸酯的包结。
【Abstract】 The inclusion condition of vitamin A acetate with β-cyclodextrin was studied.The effects of titration rate of the guest,solvent and temperature on the yield of the inclusion complex were investigated.The yield was 78.0% when vitamin A acetate 0.289 0 g in ethanol 6 mL was added dropwise in 70 min to β-cyclodextrin 1 g in water 60 mL.The total stir time was 10 h.The inclusion process was simulated by Chemoffice software.
【关键词】 维生素A醋酸酯;
β-环糊精;
包结;
分子模拟;
【Key words】 vitamin A acetate; β-cyclodextrin; inclusion; molecular simulation;
【Key words】 vitamin A acetate; β-cyclodextrin; inclusion; molecular simulation;
【基金】 国家自然科学基金项目(20705031);福建省教育厅资助项目(JB07144)
- 【文献出处】 应用化工 ,Applied Chemical Industry , 编辑部邮箱 ,2009年08期
- 【分类号】TQ466.1
- 【被引频次】4
- 【下载频次】200