【摘要】 目的观察A+C群脑膜炎球菌多糖疫苗大规模接种后的速发接种反应。方法以A+C群脑膜炎球菌多糖疫苗为观察组,伤寒Vi多糖疫苗为对照组,按组群随机分层配对的原则,将观察现场分为108个组群,观察组和对照组各分配54个组群进行接种。建立接种反应监测系统,按统一表格和方法对两组的速发接种反应进行监测。结果两组共接种34 543人,其中A+C群脑膜炎球菌多糖疫苗接种18 167人,伤寒Vi多糖疫苗接种16 376人。A+C群脑膜炎球菌多糖疫苗速发接种反应率为0.44‰;伤寒Vi多糖疫苗速发接种反应率为0.79‰,二者差异无统计学意义;速发接种反应均出现在接种后15 min内,最早的出现在接种后5 min,速发接种反应中有2例为异常反应,但未出现严重反应。结论A+C群脑膜炎球菌多糖疫苗速发接种反应发生率低,预后良好。更多还原

【Abstract】 Objective To observe the immediate adverse reaction after mass vaccination of groups A+C meningococcalpolysaccharide vaccine.Methods The populations in field were divided into 108 clusters consisting of 54 trial and 54 control clus-ters according to the principle of cluster randomization stratified and paired sampling,and vaccinated with groups A+C meningococcalpolysaccharide vaccine and typhoid Vi polysaccharide vaccine respectively.An adverse event surveillance system was established tomonitor the immediate reactions following vaccination campaign.Results A total of 34 543 persons were vaccinated,of whom18 167 with groups A+C meningococcal polysaccharide vaccine and 16 376 with typhoid Vi polysaccharide vaccine.The immediateadverse reaction rates after vaccination with groups A+C meningococcal polysaccharide vaccine and typhoid Vi polysaccharide vaccinewere 0.44‰ and 0.79‰ respectively,which showed no significant difference.All the immediate adverse reactions appeared within15 min after vaccination,of which the earliest one within 5 min.Two cases of abnormal reactions were observed,but on severe reac-tion.Conclusion The immediate adverse reaction rate after vaccination of groups A+C meningococcal polysaccharide vaccine waslow,indicating good safety of the vaccine.更多还原